Evidence map›Paper›PMID 42185328›Full record

ArticleNPJ genomic medicine2026

Expanding the phenotypic spectrum of FGF12-epilepsy-does prompt precision therapy affect outcomes?

Leo Arkush, Kristina Karandasheva, Frédérique Ouellet, Alissa M D'Gama, Beth Rosen Sheidley, Nicole S Y Liang, Vann Chau, Gregory Costain, Lacey Smith, Anoushka Alwis and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ genomic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Leo ArkushPediatric Neurology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Kristina KarandashevaInstitute of Neuropathology, Universitätsklinikum Erlangen, Erlangen, Germany.
Frédérique OuelletDivision of Neurology, The Hospital for Sick Children (SickKids), Toronto, ON, Canada.
Alissa M D'GamaEpilepsy Genetics Program, Boston Children's Hospital, Boston, MA, USA.
Beth Rosen SheidleyEpilepsy Genetics Program, Boston Children's Hospital, Boston, MA, USA.
Nicole S Y LiangDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Vann ChauDivision of Neurology, The Hospital for Sick Children (SickKids), Toronto, ON, Canada.
Gregory CostainDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Lacey SmithDepartment of Neurology, Boston Children's Hospital, Boston, MA, USA.
Anoushka AlwisNeurology, Great Ormond Hospital for Children, London, UK.
Christin EltzeNeurology, Great Ormond Hospital for Children, London, UK.
Annapurna PoduriEpilepsy Genetics Program, Boston Children's Hospital, Boston, MA, USA.
Felice D'ArcoNeuroradiology, Great Ormond Hospital for Children, London, UK.
Josh AdamsDivision of Pediatric Neurology, University of Michigan, Ann Arbor, MI, USA.
Kristen LeeDivision of Pediatric Genetics, Metabolism and Genomic Medicine, Ann Arbor, MI, USA.
Jaspal SinghDepartment of Paediatric Neurology, University Hospital Southampton, Southampton, UK.
Alexander P Y BrownInfection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, UK.
Arjuna NagendranDepartment of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, London, UK.
Ben Pode-ShakkedGray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Michal TzadokPediatric Neurology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Bruria Ben ZeevPediatric Neurology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Amy McTagueNeurology, Great Ormond Hospital for Children, London, UK. a.mctague@ucl.ac.uk.

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Action Medical Research GN3074CIHR PJT186240; EHC-201202Medical Research Council MR/T007087/1NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Fibroblast growth factor-12 (FGF12) variants have been associated with developmental and epileptic encephalopathy (DEE) with evidence of modulation of voltage-gated sodium channels Na

Identifiers

PMID42185328
PMCPMC13385693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.