Evidence map›Paper›PMID 42185318›Full record

ArticleNature communications2026

Large-scale investigation for antimicrobial activity reveals newly-identified defensive species across the healthy skin microbiome.

Uyen Thy Nguyen, Rauf Salamzade, Shelby Sandstrom, Mary Hannah Swaney, Elizabeth C Townsend, Sherrie Y Wu, J Z Alex Cheong, Joseph A Sardina, Isabelle Ludwikoski, Mackinnley Rybolt and 9 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Uyen Thy Nguyen *Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Rauf Salamzade *Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Shelby Sandstrom *Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mary Hannah SwaneyDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Elizabeth C TownsendDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID http://orcid.org/0000-0003-3102-8033
Sherrie Y WuDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID http://orcid.org/0009-0004-6956-5357
J Z Alex CheongDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID http://orcid.org/0000-0002-1127-9970
Joseph A SardinaDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Isabelle LudwikoskiDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mackinnley RyboltDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Hanxiao WanDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Caitlin M CarlsonDepartment of Bacteriology, College of Agriculture and Life Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jordana FerroDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Owen McArthurDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Won Se SuhDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0009-0007-6948-3396
Robert ZarnowskiDepartment of Medicine, Division of Infectious Disease, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID http://orcid.org/0000-0001-6343-1500
David R AndesDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID http://orcid.org/0000-0002-7927-9950
Cameron R CurrieDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-3104-3997
Lindsay R KalanDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA. kalanlr@mcmaster.ca.ORCID http://orcid.org/0000-0003-4980-5128

Funding

Novel antimicrobials targeting MDR pathogens from animal microbial symbiontsU19AI142720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R · 2019 to 2023
$30.1M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Elucidating the Role of Microbial Community Dynamics in Wound Repair and RegenerationR35GM137828 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KALAN, LINDSAY ROBYN · 2020 to 2021
$750k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U19AI142720NIAID NIH HHS U19 AI142720NIGMS NIH HHS R35 GM137828NIGMS NIH HHS T32 GM140935U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM137828
6 · The paper itself

Abstract

The skin microbiome forms a protective barrier to pathogens, including through the production of antimicrobial metabolites. Here, we present EPIC

Indexed as

Anti-Infective AgentsBacteriaMicrobiotaSkinSkin MicrobiomeHumansMetagenomeMultigene FamilyPhylogenyAnti-Infective Agents

Identifiers

PMID42185318
PMCPMC13385363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.