A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity.

Bau-Lin Huang, Sean Davis, Eiki Koyama, Maurizio Pacifici, Susan Mackem

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
A pivotal role for Wnt antagonists in constraining Wnt activity to promote digit joint specification.2025

5 · Who and what money

Authors and funding

5 authors.

Bau-Lin HuangCancer & Developmental Biology Laboratory, CCR, National Cancer Institute, Frederick, MD, USA.ORCID http://orcid.org/0000-0003-3747-6697

Sean DavisGenetics Branch, CCR, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8991-6458

Eiki KoyamaTranslational Research Program in Pediatric Orthopaedics,Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Maurizio PacificiTranslational Research Program in Pediatric Orthopaedics,Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Susan MackemCancer & Developmental Biology Laboratory, CCR, National Cancer Institute, Frederick, MD, USA. mackems@mail.nih.gov.ORCID http://orcid.org/0000-0002-9095-9914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bmps and Wnts often act antagonistically. Here we report that in mouse digit progenitors, unlike long bone joints, they cooperate to promote chondrogenic over joint (interzone) commitment. Elevated Bmp signaling prevents 5'Hoxd

Indexed as

JointsWnt ProteinsAnimalsbeta CateninBone Morphogenetic ProteinsChondrogenesisGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaIntercellular Signaling Peptides and ProteinsMiceSmad1 ProteinWnt Signaling Pathwaybeta CateninBone Morphogenetic ProteinsGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGsk3b protein, mouseIntercellular Signaling Peptides and ProteinsSmad1 ProteinWnt Proteins

Identifiers

PMID42185307

DOI10.1038/s41467-026-73549-4

PMCPMC13389162

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.