ArticleNature communications2026
Dehydration promotes intracellular lipid synthesis and accumulation.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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46 authors.
Joshua S CartyDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Jazlyn SelvasinghDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0009-0009-3832-8419
Yvonne ZuchowskiDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-5253-7366
Hyuck-Jin NamMolecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-9489-6439
Clothilde PénalvaMolecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-5360-8106
Gayani NanayakkaraMolecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.
Erin Q JenningsDivision of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6991-6098
Kelsey VossDepartment of Pathology Microbiology and Immunology, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1732-2682
Edith T AdameDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0009-0002-7398-5181
John T TossbergDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Wei Sheng YapCell Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-5411-2548
Meiling MelzerDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0009-0001-3935-3159
Olga ViquezDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
A Scott McCallDivision of Allergy, Pulmonary, and Critical Care, Department of Medicine, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Elizabeth R PiotrowskiDepartment of Integrative Biology, University of California, Berkeley, CA, USA.
Ryoichi BesshoDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Shirong CaoDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6593-4600
Katrina L LeaptrotDepartment of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-9266-145X
Alexandra C Schrimpe-RutledgeDepartment of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-7086-1170
Simona G CodreanuDepartment of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4435-812X
Stacy D SherrodDepartment of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-2346-230X
John A McLeanDepartment of Chemistry and Center for Innovative Technology; Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8918-6419
Jonathan B TrapaniDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Matthew A CottamThe Vanderbilt Creative Data Solutions Shared Resource, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0619-1605
Ma WanEpigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Deepti ShrivastavaEpigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Don A DelkerEpigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Matthew H WilsonDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Clinton M HasenourDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Louise LantierDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6620-4976
Irene ChernovaSection of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Jamey D YoungDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0871-1494
Volker H HaaseDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7051-8994
Jose Pablo Vazquez-MedinaDepartment of Integrative Biology, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1014-5214
Dylan K KosmaDepartment of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA.ORCID http://orcid.org/0000-0002-6880-7260
Peter K KimCell Biology Program, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-6626-0575
Jean-Philippe CartaillerThe Vanderbilt Creative Data Solutions Shared Resource, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0312-2391
Mingzhi ZhangDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0980-2419
Roy ZentDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.
Raymond C HarrisDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8025-0883
Jason A WattsEpigenetics and RNA Biology Laboratory and Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Andrew S TerkerDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1498-9043
Fabian BockDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0788-2945
Jeffrey C RathmellVanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-4106-3396
Aylin R RodanMolecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-9202-2378
Juan P ArroyoDivision of Nephrology and Hypertension, Vanderbilt University Medical Center; 1161 21st Ave South, Nashville, TN, USA. juan.p.arroyo@vumc.org.ORCID http://orcid.org/0000-0002-5992-5011
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MMolecular Mechanisms of Renal InjuryR01DK081646 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAASE, VOLKER HANS · 2008 to 2021
$4.3MControl of the Renal WNK Signaling Pathway by Phase TransitionsR01DK098145 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AYLIN RACHEL RODAN, AROHAN R SUBRAMANYA · 2014 to 2026
$4.2MRegulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1MThe Biology of Peroxiredoxin 6R35GM146951 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Jose P Vazquez Medina · 2022 to 2026
$2.1MThe Effect of Sodium (Na+) on Kidney B cells in Lupus NephritisK08DK133496 · NIDDK · YALE UNIVERSITY · PI Irene Chernova · 2022 to 2026
$885kUnderstanding the physiology and pathophysiology of kidney-derived vasopressinK08DK135931 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Juan Pablo Arroyo Ornelas · 2023 to 2026
$696kRac1 and the actin cytoskeleton in renal tubular repairK08DK134879 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Fabian Maximilian Bock · 2023 to 2026
$636kMitochondrial electron transport dysfunction: Dissecting pathomechanismsR21AG082416 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAASE, VOLKER HANS · 2023 to 2024
$481kBLRD VA I01 BX002348NIA NIH HHS R21 AG082416NIDDK NIH HHS K08 DK133496NIDDK NIH HHS K08 DK134879NIDDK NIH HHS K08 DK135931NIDDK NIH HHS R01 DK081646NIDDK NIH HHS R01 DK098145NIDDK NIH HHS R01 DK110358NIGMS NIH HHS R35 GM146951NIH HHS P40 OD018537U.S. Department of Health & Human Services | National Institutes of Health (NIH) K08-DK135931
Abstract
Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration and the ensuing hypertonic stress directly regulate lipid synthesis is unknown. We show that hypertonic stress decreases cellular oxygen consumption, increases intracellular lipid synthesis, and favors glutamine oxidation as a carbon precursor for lipid synthesis via remodeling mitochondrial metabolism. These findings provide a mechanism whereby cellular dehydration leads to intracellular lipid accumulation, functionally linking water availability to lipid storage.
Indexed as
DehydrationLipid MetabolismLipidsAnimalsGlutamineHumansMitochondriaOxidation-ReductionOxygen ConsumptionGlutamineLipids
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