In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Gabriel Baonza *Program of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Tatiana Alfonso-Pérez *Program of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. talfonso@cbm.csic.es.ORCID http://orcid.org/0000-0003-1421-9217 Carlos Quintana-QuintanaProgram of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Gonzalo HerranzProgram of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Carmen Gordillo-VázquezInstituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Sevilla (US). Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla (US), Sevilla, Spain.
Yara El MazjoubDepartment of Cells and Tissues, Instituto de Biología Molecular de Barcelona (IBMB), Parc Científic de Barcelona, Baldiri i Reixac 20, Barcelona, Spain.ORCID http://orcid.org/0009-0000-8901-0472 L M EscuderoInstituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Sevilla (US). Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla (US), Sevilla, Spain.ORCID http://orcid.org/0000-0001-8030-1820 David G MíguezProgram of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID http://orcid.org/0000-0001-8065-1142 Nuria Martínez-MartínProgram of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. nmartinez@cbm.csic.es.ORCID http://orcid.org/0000-0003-2309-8920 Fernando Martín-BelmonteProgram of Tissue and Organ Homeostasis, Centro de Biología Molecular "Severo Ochoa" (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. fmartin@cbm.csic.es.ORCID http://orcid.org/0000-0002-2564-4430 Funding
Ministerio de Economía, Industria y Competitividad, Gobierno de España (Ministerio de Economía, Industria y Competitividad) PID2020-120367GB-I00
6 · The paper itselfAbstract
Epithelial tubulogenesis shapes organs by transforming unpolarized epithelial cords into hollow tubes with central lumens. Posterior neural tube formation during secondary neurulation requires tightly coordinated membrane remodeling for de novo lumen formation and resolution, yet the role of autophagy in this process remains unclear. Autophagy operates through canonical and noncanonical pathways. While canonical autophagy is primarily degradative, the V-ATPase/ATG16L1-dependent Conjugation of ATG8 to Single Membranes (CASM) regulates LC3 lipidation on endocytic compartments. Using human neural tube organoids, MDCK cysts, and epithelial tube micropatterns selectively deficient in canonical or noncanonical autophagy, we demonstrate that CASM is essential for epithelial lumen resolution. Mechanistically, the V-ATPase/ATG16L1 axis coordinates junctional remodeling, phosphoinositide transitions, and Rab-dependent endocytic and recycling pathways to ensure single-lumen formation. These findings identify noncanonical autophagy as a spatially restricted membrane-remodeling mechanism that governs epithelial morphogenesis and reveal distinct, hierarchically balanced contributions of autophagy pathways during development.
Indexed as
Autophagy-Related ProteinsCell MembraneMorphogenesisVacuolar Proton-Translocating ATPasesAnimalsAutophagyDogsEpithelial CellsEpitheliumHumansMadin Darby Canine Kidney CellsMicrotubule-Associated ProteinsNeural TubeAutophagy-Related ProteinsMicrotubule-Associated ProteinsVacuolar Proton-Translocating ATPases
Identifiers
PMID42185297
PMCPMC13385949
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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