Evidence map›Paper›PMID 42185283›Full record

ArticleNature communications2026

Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter.

I-Chi Lee, Po-Hsuan Lai, Chen-Wei Tsai, Yung-Chi Tu, Yu-Chen Huang, Wei-Chen Chen, Ming-Feng Tsai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

I-Chi Lee *Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Po-Hsuan Lai *Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Chen-Wei TsaiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Yung-Chi TuDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0009-0007-5074-4883
Yu-Chen HuangDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Wei-Chen ChenDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ming-Feng TsaiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA. vmf6uw@virginia.edu.ORCID http://orcid.org/0000-0003-4277-1885

Funding

Molecular mechanisms of the mitochondrial calcium transport systemR35GM151958 · NIGMS · UNIVERSITY OF VIRGINIA · PI Ming-Feng Tsai · 2024 to 2026
$1.6M
NIGMS NIH HHS R35 GM151958U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM151958
6 · The paper itself

Abstract

The mitochondrial Ca

Indexed as

CalciumCalcium ChannelsMitochondriaMitochondrial Membrane Transport ProteinsAnimalsCalcium SignalingHEK293 CellsHumansProtein BindingProtein DomainsCalciumCalcium Channelsmitochondrial calcium uniporterMitochondrial Membrane Transport Proteins

Identifiers

PMID42185283
PMCPMC13385820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.