ArticleNature communications2026
Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals.Nature communications · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
The thyroid has a remarkable evolution, transforming from an exocrine constituent of the chordate endostyle to an endocrine gland in basal vertebrates. In mammals, a second endocrine cell type of presumed neural crest origin appears, although recent lineage tracing has firmly established thyroid C-cells are also endoderm-derived. Here, we characterize the global gene expression in both embryonic thyroid lineages at single-cell level and identify lineage-specific transcription factors and their network regulation of target genes implicated in thyroid development into a dual endocrine organ. Merging of the pharyngeal pouch-derived ultimobranchial bodies with the midline thyroid primordium is an ordered process featuring basement membrane dynamics and epithelial-mesenchymal plasticity required for precursor cells to disseminate and properly integrate, thus forming the typical histoarchitecture of thyroid follicles and parafollicular C-cells. Synchronous lineage growth of compound follicles is recapitulated in mixed-type thyroid carcinoma in which only the neuroendocrine tumor cells escape the follicle basement membrane boundaries and become invasive adopting a C-cell precursor-like migratory phenotype.
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