ArticleNature communications2026
A highly sensitive genetically encoded red cAMP sensor for multiplex imaging in vivo.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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18 authors.
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Abstract
Circularly permuted green fluorescent protein (cpGFP)-based high-performance cAMP sensors have enabled real-time monitoring of cAMP dynamics with high spatiotemporal resolution in living animals. However, their utility is hampered by significant spectral overlap with other green/yellow fluorescent indicators and blue/cyan light-activated optogenetic actuators, limiting their compatibility in multiplexed imaging applications. While existing red cAMP sensors offer great spectral separation, they often suffer from a limited dynamic range ( < 1.5-fold in HEK293T cells), low cellular brightness, aggregation, or significant blue-light-induced photoactivation. Here, we report R-Flamp1, a red cAMP sensor with a large dynamic range ( > 10-fold in HEK293T cells), enhanced cellular brightness, appropriate cAMP affinity (K
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