Evidence map›Paper›PMID 42185267›Full record

ArticleNature communications2026

Diversification in ANME-1 archaea is associated with the presence of highly variable genomic hotspots.

Ying-Li Zhou, Jing-Chun Feng, Rui Lu, Zhe Chen, Paraskevi Mara, Xuanyu Tao, Jinyi Liu, Yongji Huang, Junlin Hu, Jianyun Yao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ying-Li Zhou *Research Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.ORCID http://orcid.org/0000-0002-3757-0029
Jing-Chun Feng *Research Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China. fengjc@gdut.edu.cn.ORCID http://orcid.org/0000-0002-6819-8645
Rui Lu *Research Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.
Zhe Chen *State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Paraskevi Mara *Geology and Geophysics Department, Woods Hole Oceanographic Institution, Woods Hole, MA, USA.ORCID http://orcid.org/0000-0003-0072-0238
Xuanyu TaoResearch Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.
Jinyi LiuInstitute of Smart Ocean Science and Engineering, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou, China.
Yongji HuangResearch Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.
Junlin HuResearch Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.
Jianyun YaoState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Virginia P EdgcombGeology and Geophysics Department, Woods Hole Oceanographic Institution, Woods Hole, MA, USA.ORCID http://orcid.org/0000-0001-6805-381X
Andreas TeskeDepartment of Earth, Marine and Environmental Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3669-5425
Xiaoxue WangState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0002-7257-1916
Si ZhangResearch Centre of Ecology & Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China. zhsimd@scsio.ac.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 42325603National Natural Science Foundation of China (National Science Foundation of China) 42494884
6 · The paper itself

Abstract

Anaerobic methanotrophic (ANME) archaea have been primarily documented by metagenomic analysis of environmental samples. The mechanisms that drive their diversification and speciation are poorly understood. Here we analyse the phylogenomic diversity at the species and strain levels of clade ANME-1 from deep-sea cold seeps, as a model system with a well-studied phylogenetic framework. We reconstruct high-quality circular metagenomic-assembled genomes (cMAGs) and identify highly variable genomic hotspots that distinguish them. Genomic differentiation and diversification in ANME-1 is associated with genes involved in prokaryotic defense systems, transport mechanisms and methane metabolism. In addition, heterologous expression of ANME-1 hicAB operons supports their proposed role as toxin/antitoxin systems, possibly involved in mediating responses to environmental stresses.

Indexed as

ArchaeaGenetic VariationGenome, ArchaealMetagenomicsMethaneOperonPhylogenyMethane

Identifiers

PMID42185267
PMCPMC13385816

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.