Evidence map›Paper›PMID 42185260›Full record

ArticleNature communications2026

HBV HBx protein masks epigenetic reader Spindlin1 via an inter-molecular zinc finger to subvert transcriptional control.

Alexis Clavier, Toshinobu Shida, Maxim A Droemer, Santiago Gómez-Evain, Franziska von Hammerstein, Julian Holzinger, Mila M Leuthold, Céline Douat, Anne K Schütz

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexis Clavier *Faculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.ORCID 0000-0003-2318-4597
Toshinobu Shida *Faculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.ORCID 0009-0007-2473-0664
Maxim A DroemerFaculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.ORCID 0009-0009-5280-2041
Santiago Gómez-EvainFaculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.ORCID 0009-0004-7353-5548
Franziska von HammersteinFaculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.
Julian HolzingerFaculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.ORCID 0000-0002-0530-8413
Mila M LeutholdDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany.ORCID 0000-0001-7698-2360
Céline DouatFaculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany.ORCID 0000-0003-2678-1047
Anne K SchützFaculty for Chemistry and Pharmacy, Ludwig-Maximilians-Universität München (LMU), München, Germany. anne.schuetz@cup.lmu.de.ORCID 0000-0001-6398-5757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HBx protein from Hepatitis B virus (HBV) is essential for replication and promotes pathogenicity during chronic infection. HBx hijacks host proteins, reprogramming them to evade antiviral defence. However, the structural basis of recruitment remains largely unknown. The HBx

Indexed as

Cell Cycle ProteinsHepatitis B virusMicrotubule-Associated ProteinsPhosphoproteinsTrans-ActivatorsZinc Fingersbcl-X ProteinDNA, ViralEpigenesis, GeneticHost-Pathogen InteractionsHumansProtein BindingTranscription, GeneticViral Regulatory and Accessory Proteinsbcl-X ProteinCell Cycle ProteinsDNA, Viralhepatitis B virus X proteinMicrotubule-Associated ProteinsPhosphoproteinsTrans-ActivatorsViral Regulatory and Accessory Proteins

Identifiers

PMID42185260
PMCPMC13213052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.