Evidence map›Paper›PMID 42185250›Full record

ArticleBone research2026

Bacterial specificity of the gut microbiome predicts bone density in primary hyperparathyroidism.

Hamid Y Dar, Jiali Fang, Sanchiti Patil, Nand K Roy, Sanchita Agarwal, M Neale Weitzmann, Rheinallt M Jones, John P Bilezikian, Roberto Pacifici

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamid Y DarDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-4018-4559
Jiali FangDivision of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Sanchiti PatilDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Nand K RoyDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Sanchita AgarwalDivision of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
M Neale WeitzmannDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0003-3305-5748
Rheinallt M JonesEmory Microbiome Research Center, Emory University, Atlanta, GA, USA.
John P BilezikianDivision of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Roberto PacificiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA. roberto.pacifici@emory.edu.ORCID 0000-0001-6077-8250

Funding

NCRR NIH HHS RR028009NIDDK NIH HHS DK09839U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK124821
6 · The paper itself

Abstract

Primary hyperparathyroidism causes mild-to-severe bone loss, but the reason for this heterogeneity is unclear. We investigated the role of the microbiome in 50 primary hyperparathyroidism patients. Microbiome transfers from primary hyperparathyroidism patients with and without osteoporosis to germ-free mice replicated the human bone phenotype and regulated TNF

Indexed as

Bone DensityGastrointestinal MicrobiomeHyperparathyroidism, PrimaryAnimalsFemaleHumansMaleMiceMiddle AgedTh17 CellsTumor Necrosis Factor-alphaTumor Necrosis Factor-alpha

Identifiers

PMID42185250
PMCPMC13201753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.