ArticleACS nano2026
Wireless Electromagnetic Generation of miRNA Sponges and Nerve Stimulation by an Adaptable Electrical Scaffold for Repair of Traumatic Brain Injury.
Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioelectronic transduction and microRNA (miRNA) regulation play crucial roles in shaping neuronal cell fate and supporting brain repair. However, clinical progress remains limited due to the lack of tools to perform spatiotemporal regulation of neuronal electrical activity and nonviral gene regulation in vivo. In this study, an adaptable electronic scaffold (AES) that functions both as an antenna and gene transfection agent was developed for neuron miRNA modulation in traumatic brain injury (TBI). The intrinsic properties of AES alleviate inflammation and glial scarring after TBI by suppressing activated microglia and stellate cells. Under high-frequency magnetic field (HFMF) stimulation, the "wireless messenger" generates localized electrical cues that aid in restoring brain function as well as enhancing neuronal uptake of gene therapeutics via electroporation. In neurons, AES-induced Eddy currents and mechanical forces further promote endosome escape and the formation of miRNA sponges both in vitro and in vivo, thereby reducing the increase in miR-6236 levels after neuronal injury. The synergic effects achieve in situ gene modulation, promotes neurite outgrowth, and enhance angiogenesis within the lesion. In whole-brain diffusion-weighted magnetic resonance imaging (dMRI), the signal bundles reveal improved intercortical and cortical stellate fiber connectivity, and a recovery in motor function. In summary, this wirelessly driven gene regulation platform combines miRNA-targeted therapy with bioelectronic stimulation to achieve precise neuroregenerative intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.