Evidence map›Paper›PMID 42185184›Full record

ArticleUltrasound in medicine & biology2026

Safety and Efficacy of Histotripsy Treatments Near Implanted Metallic Fiducials and Endovascular Coils in Phantoms and in an In Vivo Swine Model.

Katrina L Falk, Martin G Wagner, Claire Hennen, Tyler J Schluter, Saryn Doucette, Michael A Speidel, Grace M Minesinger, Adrienne L Kisting, Ali Mutlu, Gretchen M Foltz and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Katrina L FalkDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Engineering Centers Building, Madison, WI, USA. Electronic address: katrina.falk@wisc.edu.
Martin G WagnerDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Claire HennenHistoSonics Inc, Plymouth, MN, USA.
Tyler J SchluterDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Saryn DoucetteDepartment of Pathology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Michael A SpeidelDepartment of Medical Physics, University of Wisconsin-Madison, Madison WI, USA; Department of Medicine, University of Wisconsin-Madison, Madison WI, USA.
Grace M MinesingerDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison WI, USA.
Adrienne L KistingDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Ali MutluDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Gretchen M FoltzDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Fred T LeeDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA; Department of Urology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA.
Paul F LaesekeDepartment of Radiology, University of Wisconsin-Madison, Clinical Sciences Center, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Engineering Centers Building, Madison, WI, USA.

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Advanced multimodal image-guided histotripsy for precise, safe and effective histotripsy of liver tumorsR01EB031007 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F Laeseke, Martin Gerd Wagner · 2022 to 2026
$2.5M
Developing Methods for Precise, Safe and Target-location Specific Histotripsy of Liver TumorsR01CA262474 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ZIEMLEWICZ, TIMOTHY J · 2021 to 2025
$2.4M
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver TumorsF30CA284541 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Katrina Lauren Falk · 2024 to 2026
$135k
NCI NIH HHS F30 CA284541NCI NIH HHS R01 CA262474NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB031007NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

objectiveThis work evaluated the safety and efficacy of histotripsy treatments with metal in the therapeutic beam path or directly in the treatment zone.

methodsHistotripsy treatments were performed on 66 agar phantoms with metal nearfield, adjacent to and within the treatment zone. Two endovascular coil sizes, a surgical clip and three gold fiducials were tested. The energy required to treat, treatment size and Dice coefficient were compared with control treatments without metal. In vivo histotripsy treatments were performed on four healthy swine (two treatments per animal). Treatments were performed centered on a metallic fiducial (n = 3) or deep to the endovascular coils (n = 3), as well as without metal in the beam path (control, n = 2). The control treatments were performed in independent areas of the liver. Imaging and gross necropsy were used to assess safety. Additionally, imaging and histology were used to assess efficacy.

resultsThe phantom treatment energy levels, diameters and Dice coefficients, as well as in vivo treatment diameters, failed to show any significant differences between the experimental and control groups. No off-target damage was observed. Histologically, the treatment zones beneath a coil and over a metal fiducial were both complete, with acellular debris surrounded by a transition zone of hepatocytes with pyknotic nuclei and atrophic sinusoidal plates.

conclusionHistotripsy with endovascular coils in the ultrasound beam path or with a metal fiducial directly in the treatment zone was safe and effective in this small, acute in vivo swine study.

Indexed as

Fiducial MarkersHigh-Intensity Focused Ultrasound AblationLiverAnimalsMetalsPhantoms, ImagingSwineTreatment OutcomeMetalsEndovascular coilsFiducialHistotripsyLiverPhantomPre-clinicalSwineTumor

Identifiers

PMID42185184
PMCPMC13334985

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.