ArticleACR open rheumatology2026
Decreased Serum Vitamin D Is Not Associated With Sjögren Disease in European and Asian Subjects.
Article in ACR open rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo identify whether serum vitamin D [25(OH)D] and vitamin D receptor-binding variants (VDR-BVs) previously implicated in multiple sclerosis (MS) are associated with Sjögren disease (SjD) susceptibility and related clinical outcomes, with the overall goal of understanding the relationship between vitamin D and SjD pathogenesis.
methodsWe constructed genetic instrumental variables (GIVs) for 25(OH)D using results from five genome-wide association studies and established VDR-BVs from experimental studies and then employed a two-sample Mendelian randomization (MR) approach. We assessed the separate associations of 25(OH)D (GIV
resultsOne VDR-BV previously found to be causally associated with MS, rs2531804, was also significantly associated with SjD (P < 0.05) in European individuals. Decreased 25(OH)D was not significantly associated with SjD overall, or when European and Asian subgroups were considered separately.
conclusionThis study is the first to investigate genetic variants implicated in previous MR studies of the vitamin D pathway in MS for a role in SjD. Although a role for decreased serum vitamin D in SjD was not supported here, results show that variation within at least one VDR causally contributes to SjD susceptibility in European individuals. Additional research is necessary to more comprehensively understand how vitamin D contributes to SjD pathogenesis across different ancestry groups.
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