Observational studyThe Journal of infectious diseases2026
Vaccine Response Assessment in Children Using Dried Blood Spots: The DRIVE Study.
Observational study in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundDried blood spots (DBS) are a minimally invasive alternative to serum for serological surveillance, but pediatric data remain limited, particularly in high-resource settings and in immunocompromised children. We evaluated the diagnostic accuracy of DBS for assessing vaccine-induced immunity in a pediatric cohort from Madrid, Spain.
methodsThis prospective observational study evaluated the diagnostic accuracy of DBS compared with serum samples in 134 children and adolescents (98 nonimmunocompromised, 36 immunocompromised) at La Paz University Hospital (Madrid, Spain). IgG antibodies against 6 vaccine-preventable diseases-diphtheria, tetanus, pertussis, measles, mumps, and rubella-were quantified using the VirClia® IgG chemiluminescence assay. ROC curves were constructed to establish optimal DBS cutoff values for each pathogen.
resultsUsing serum cutoffs, DBS showed sensitivities >95% and specificities >85% for all pathogens, except for pertussis, which had a sensitivity of 66.7%, and for rubella and mumps, which had specificities of 62.5% and 44.0%, respectively. Applying optimized DBS cutoffs improved specificity for rubella (81.2%) and mumps (88.0%). In immunocompromised children, sensitivity remained >80% for most pathogens but decreased for mumps (76.0%). Age and time since vaccination did not significantly affect DBS performance.
conclusionsDried blood spot provide a reliable and practical approach for assessing vaccine-induced immunity in children and adolescents. Their ease of collection and transport make them especially valuable in settings with limited laboratory capacity. Population-specific cutoffs are essential, particularly for immunocompromised groups, to ensure diagnostic accuracy and support global immunization monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.