Evidence map›Paper›PMID 42184970›Full record

Observational studyPediatrics2026

Prenatal Substance Exposure and Birth Weight: Findings From the HEALthy Brain and Child Development Study.

Gretchen Bandoli, Catherine Psaras, Ludmila N Bakhireva, Heather H Burris, Lucia Ciciolla, Claire D Coles, Sara B DeMauro, Sarah S Osmundson, Stephanie L Merhar, Lynne Smith and 38 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Gretchen BandoliDepartment of Pediatrics, University of California San Diego, La Jolla, California.
Catherine PsarasDepartment of Pediatrics, University of California San Diego, La Jolla, California.
Ludmila N BakhirevaThe Substance Use Research and Education (SURE) Center, University of New Mexico College of Pharmacy, Albuquerque, New Mexico.
Heather H BurrisChildren's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Lucia CiciollaDepartment of Psychology at Oklahoma State University, Stillwater, Oklahoma.
Claire D ColesDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Sara B DeMauroChildren's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Sarah S OsmundsonDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.
Stephanie L MerharCincinnati Children's Hospital and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.
Lynne SmithThe Lundquist Institute at Harbor-UCLA Medical Center, University of California Los Angeles, Los Angeles, California.
Ashley AchesonDepartment of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Ryan BogdanDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, Saint Louis, Missouri.
Julie M CroffDepartment of Rural Health, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma.
Laurie E CuttingPeabody College of Education and Human Development, Vanderbilt University, Nashville, Tennessee.
Kevin P ConwayIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
M Daniele FallinRollins School of Public Health, Emory University, Atlanta, Georgia.
Wei GaoDepartment of Biomedical Sciences and Imaging, Cedars Sinai Medical Center, Los Angeles, California.
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington, Vermont.
Kim GregoryDepartment Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California.
Kelly K GurkaDepartment of Epidemiology, University of Florida, Gainesville, Florida.
Matthew J GurkaDepartment of Biostatistics, University of Florida, Gainesville, Florida.
Holly L HoranDepartment of Obstetrics and Gynecology, Division of Global and Rural Women's Health, The University of Alabama at Birmingham, Birmingham, Alabama.
Katia D HowlettNational Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland.
Brittany R HowellFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia.
Hao HuangDepartment of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
Julie A KableDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
Kimberly H LeBlancNational Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland.
Janosch LinkersdörferJ. Craig Venter Institute, La Jolla, California.
Carla B MarienfeldDepartment of Psychiatry, University of California San Diego, San Diego, California.
Lorraine M McKelveyDepartment of Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Amanda S MorrisDepartment of Psychology, Oklahoma State University, Tulsa, Oklahoma.
Xiawei OuDepartment of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Myriam Peralta-CarcelenDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Nicolò PiniDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York.
Alexandra S PotterDepartment of Psychiatry, University of Vermont, Burlington, Vermont.
Cynthia E RogersDepartments of Psychiatry and Pediatrics, Washington University, St. Louis, Missouri.
Elinor L SullivanDepartment of Psychiatry, Steven J. Sharp Center for Mental Health Innovation, Oregon Health & Science University, Portland, Oregon.
Sophie SunLasso Informatics, Montreal, Quebec, Canada.
Wesley K ThompsonCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, Oklahoma.
Moriah E ThomasonDepartment of Child and Adolescent Psychiatry, New York University Langone Health, New York, New York.
Heather E VolkDepartment of Mental Health, Johns Hopkins University, Baltimore, Maryland.
Sylia WilsonInstitute of Child Development, University of Minnesota, Minneapolis, Minnesota.
Aleksandra E ZgierskaDepartments of Family and Community Medicine, Anesthesiology and Perioperative Medicine, and Public Health Sciences, College of Medicine, Penn State, Hershey, Pennsylvania.
Jennifer ZinkLasso Informatics, Montreal, Quebec, Canada.
Christopher D SmyserDepartments of Neurology, Pediatrics, Radiology, and Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
Charles A NelsonDepartment of Pediatrics, Harvard Medical School and Boston Children's Hospital, Cambridge, Massachusetts.
Christina D ChambersDepartment of Pediatrics, University of California San Diego, La Jolla, California.
HBCD Consortium

Funding

The Healthy Brain and Child Development National Consortium Administrative CoreU24DA055325 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTINA CHAMBERS, CHARLES Alexander NELSON · 2021 to 2026
$40.8M
Healthy Brain and Child Development National Consortium Data Coordinating CenterU24DA055330 · NIDA · WASHINGTON UNIVERSITY · PI ANDERS M DALE, Damien A Fair · 2021 to 2026
$34.6M
5/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) ConsortiumU01DA055344 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Weili Lin · 2021 to 2026
$13.9M
6/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium VanderbiltU01DA055347 · NIDA · VANDERBILT UNIVERSITY · PI Laurie E Cutting, Sarah Scheiderich Osmundson · 2021 to 2026
$12.7M
5/24 Healthy Brain and Child Development National ConsortiumU01DA055353 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI Michelle A Bosquet Enlow, Patricia Ellen Grant · 2021 to 2026
$12.1M
4/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) ConsortiumU01DA055342 · NIDA · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR, JENNIFER J. VANNEST · 2021 to 2026
$11.9M
1/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) ConsortiumU01DA055352 · NIDA · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI ASHLEY ACHESON, LORRAINE M MCKELVEY · 2021 to 2026
$11.9M
HEALthy Brain and Child Development Study at UAB and UAU01DA055322 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Rajesh K Kana, Cassandra R. Newsom · 2021 to 2026
$11.2M
23/24 Healthy Brain and Child Development National ConsortiumU01DA055367 · NIDA · WASHINGTON UNIVERSITY · PI RYAN H BOGDAN, CYNTHIA Elise ROGERS · 2021 to 2026
$10.8M
7/24 Healthy Brain and Child Development National ConsortiumU01DA055350 · NIDA · JOHNS HOPKINS UNIVERSITY · PI JAMES J. PEKAR, ANDREW J. SATIN · 2021 to 2026
$10.7M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
14/24 The Healthy Brain & Child Development National ConsortiumU01DA055369 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Gretchen E. Bandoli, CARLA B MARIENFELD · 2021 to 2026
$9.7M
Intramural NIH HHS ZIA MH002953NICHD NIH HHS P50 HD103537NIDA NIH HHS U01 DA055316NIDA NIH HHS U01 DA055322NIDA NIH HHS U01 DA055338NIDA NIH HHS U01 DA055342NIDA NIH HHS U01 DA055344NIDA NIH HHS U01 DA055347NIDA NIH HHS U01 DA055349NIDA NIH HHS U01 DA055350NIDA NIH HHS U01 DA055352NIDA NIH HHS U01 DA055353NIDA NIH HHS U01 DA055354NIDA NIH HHS U01 DA055355NIDA NIH HHS U01 DA055357NIDA NIH HHS U01 DA055358NIDA NIH HHS U01 DA055359NIDA NIH HHS U01 DA055360NIDA NIH HHS U01 DA055361NIDA NIH HHS U01 DA055362NIDA NIH HHS U01 DA055363NIDA NIH HHS U01 DA055365NIDA NIH HHS U01 DA055366NIDA NIH HHS U01 DA055367NIDA NIH HHS U01 DA055369NIDA NIH HHS U01 DA055370NIDA NIH HHS U01 DA055371NIDA NIH HHS U24 DA055325NIDA NIH HHS U24 DA055330
6 · The paper itself

Abstract

objectiveTo estimate associations of more than minimal prenatal nicotine, alcohol, cannabis, and opioid exposures with gestational age, birth weight, and birth weight for gestational age.

methodsData were drawn from the HEALthy Brain and Child Development (HBCD) Study, a multisite, longitudinal study in the United States. Predefined recruitment thresholds for each substance were assessed using maternal self-report, maternal toxicology results, and newborn substance exposure-related diagnoses. Birth outcomes included gestational age at delivery (weeks), birth weight (grams), and birth weight for gestational age (centiles). Mean differences and risk ratios for the associations between substance exposure and birth outcomes were estimated using multilevel mixed-effect linear regression or multilevel mixed-effect Poisson regression.

resultsAmong 660 mother-infant dyads, 17% (n = 115) of participants met recruitment thresholds for prenatal cannabis, 15% for nicotine (n = 102), 13% for alcohol (n = 86), and 5% for opioids (n = 32). In adjusted models, prenatal cannabis and opioid exposures were each associated with lower birth weight (cannabis: -272.2 [95% CI -444.6 to -99.8] g; opioids: -295.4 [95% CI -574.9 to -15.9] g) and birth weight centiles (cannabis: -8.2 [95% CI -15.3 to -1.1] centiles; opioids: -14.4 [95% CI -25.5, -3.4] centiles), although the results were sensitive to model specifications. Prenatal nicotine and alcohol estimates were in similar directions but not statistically significant. No significant associations between exposures and gestational age at delivery were detected.

conclusionsIn this initial HBCD Study data release, more than minimal exposure to cannabis and opioids was associated with smaller birth size, adding evidence to an inconsistent literature. Future studies from HBCD can more deeply interrogate timing and dose of each substance and expand to childhood outcomes.

Indexed as

Birth WeightChild DevelopmentPrenatal Exposure Delayed EffectsSubstance-Related DisordersAdultAnalgesics, OpioidFemaleGestational AgeHumansInfant, NewbornLongitudinal StudiesMaleNicotinePregnancyUnited StatesAnalgesics, OpioidNicotine

Identifiers

PMID42184970
PMCPMC13426249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.