Evidence map›Paper›PMID 42184826›Full record

ArticleCell stem cell2026

Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems.

Woo Sub Yang, Mu Seog Choe, Cynthia Lo, Hui-Wen Liu, Yoon Mi Cho, Jonghun Kim, Ferdi Ridvan Kiral, Michael Scandura, Xiaona Lu, Kun-Yong Kim and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Woo Sub YangDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Mu Seog ChoeDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Cynthia LoDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Hui-Wen LiuSchool of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea.
Yoon Mi ChoDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Jonghun KimDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Ferdi Ridvan KiralDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Michael ScanduraDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Xiaona LuDepartment of Genetics, Pediatrics, Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Kun-Yong KimDepartment of Genetics, Pediatrics, Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Kyuhwan NaLife solution team, Samsung Research, Samsung Electronics, Seoul R&D Campus, 33 Seongchon-gil, Secho-gu, Seoul 06765, Republic of Korea.
Caihong QiuDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Fan WuDiagnostic Biochips Inc., Glen Burnie, MD, USA.
Andrew DirksDiagnostic Biochips Inc., Glen Burnie, MD, USA.
Rebecca MathewData, AI & Genome Sciences, Merck & Co., Inc., Cambridge, MA, USA.
Bilal CakirData, AI & Genome Sciences, Merck & Co., Inc., Cambridge, MA, USA.
Hyuk-Jin ChaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Sangwon F KimDepartment of Medicine, and Neuroscience, Johns Hopkins University, Baltimore, MD 21224, USA.
Andrew CoxDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA.
Seok ChungSchool of Mechanical Engineering, Korea University, Seoul 02841, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea; Absology, Anyang 14057, Republic of Korea; Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Yong-Hui JiangDepartment of Genetics, Pediatrics, Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Kunyoo ShinInstitute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Sang-Hun LeeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
In-Hyun ParkDepartment of Genetics, Interdepartmental Neuroscience Program, Yale Stem Cell Center, Yale Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: inhyun.park@yale.edu.

Funding

Construction of the integrated human forebrain organoids to investigate neurodevelopmental disordersR01MH118344 · NIMH · YALE UNIVERSITY · PI In-Hyun Park · 2019 to 2026
$4.0M
NIMH NIH HHS R01 MH118344
6 · The paper itself

Abstract

Human emotional and stress responses are orchestrated by subcortical limbic circuits, with the amygdala playing a central role in integrating affective, sensory, and endocrine signals. Despite the urgent need to understand how these circuits develop and contribute to anxiety and stress-related disorders, progress has been hindered by lack of ex vivo human models. Here, we generated human amygdala-like telencephalic organoids (hATOs) that recapitulate cellular composition, region-specific development, and key features of the amygdala. By assembling hATOs with a hypothalamic organoid (hypoTO) with paraventricular nucleus (PVN)-like features, we modeled the amygdala-hypothalamus-like interaction, which enabled circuit-level analysis of stress-responsive signaling. Exposure to cortisol led to robust upregulation of BCYRN1, a primate-specific retrotransposon-derived noncoding RNA, which uncovered a previously unrecognized mechanism of stress hormone signaling to retrotransposon biology and human-specific synaptic regulation. These findings highlight the potential of hATOs to understand molecular features of affective circuitry underlying emotion and the stress response and neuropsychiatric disorders.

Indexed as

AmygdalaModels, BiologicalOrganoidsStress, PhysiologicalTelencephalonAnimalsHumansHydrocortisoneHydrocortisoneamygdalaassembloidsBCYRN1brain organoidsdevelopmentstem cellsstress

Identifiers

PMID42184826
PMCPMC13289835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.