Evidence map›Paper›PMID 42184746›Full record

ArticlePoultry science2026

RNA-seq reveals differentially expressed genes involved in catecholamine synthesis and metabolism in the hypothalamus affecting divergent residual feed intake in slow-growing Korat chickens.

Panpradub Sinpru, Orapin Jantasaeng, Phocharapon Pasri, Boonyarit Kamkrathok, Saknarin Pengsanthia, Tom E Porter, Wittawat Molee, Amonrat Molee

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Panpradub SinpruSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Orapin JantasaengSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Phocharapon PasriSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Boonyarit KamkrathokSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Saknarin PengsanthiaSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Tom E PorterDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, United States.
Wittawat MoleeSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Amonrat MoleeSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand. Electronic address: amonrat@sut.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Korat chicken (KRC), a slow-growing chicken known for its unique meat flavor and nutritional value, exhibits variation in feed efficiency (FE). Since the hypothalamus acts as a convergent and integrative center for multiple nutrient-related signals, this study aims to compare transcriptomic profiles and neuronal pathways in hypothalamus between two groups of male KRCs differing in residual feed intake (RFI). RNA was extracted from hypothalamic tissues of males KRC either in the low-RFI (n = 10) or in the high-RFI (n = 10) group. The results showed 257 DEGs, including 138 upregulated and 119 downregulated genes in the low RFI compared to the high-RFI groups. Gene Ontology analysis of the DEGs revealed that they were mainly related to metabolic processes and transporter activity. Kyoto Encyclopedia of Genes and Genomes pathway analysis identified 3 significant pathways, including the folate biosynthesis (3 genes including GCH1, TPH2, and TH), tyrosine metabolism (3 genes including DDC, TH and FAH), and tryptophan metabolism (3 genes including DDC, TPH2, and TDO2) pathways. The upregulated genes in the low-RFI group (TPH2, DDC, and TH) were enriched in the folate biosynthesis, tyrosine metabolism, and tryptophan metabolism pathways, which is consistent with the observed plasma concentrations of dopamine (DA) and serotonin/5-hydroxytryptamine (ST/5-HT). These findings suggest that differences in DA and ST/5-HT levels among the chicken groups may be associated with variation in FE. Furthermore, genes such as GCH1, TPH2, DDC, TH, and FAH could be candidate genes supporting the role of hypothalamus in regulating FE of slow-growing KRC.

Indexed as

CatecholaminesChickensEatingHypothalamusTranscriptomeAnimalsGene Expression ProfilingMaleRNA-SeqCatecholaminesFeed efficiencyHypothalamusResidual feed intakeRNA-seqSlow-growing chicken

Identifiers

PMID42184746
PMCPMC13223840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.