ReviewCurrent opinion in structural biology2026
Physical genomics: Why gene regulation is tug of war between polymer physics and biochemistry.
Review in Current opinion in structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
DNA-protein interactions underlie genome activity, governing gene expression as well as the physical organisation of DNA. Until recently, DNA-protein complexes were predominantly described at atomic resolution using short DNA fragments, concealing how proteins recognise and manipulate the long, supercoiled DNA present in cells. Now single-molecule imaging and cryo-electron microscopy (cryo-EM) are showing how longer DNA sequences are recognised by proteins and computations are predicting how these elements influence larger-scale genomic structures. Here we discuss how the polymeric nature of DNA influences its atomic-level structure and dynamics, as well as the implications for DNA recognition and ultimately biological function. We emphasise how theory and simulation help interpret these effects, which are difficult to replicate using conventional experimental settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.