ArticleCardiorenal medicine2026
Tubular Biomarkers N-Acetyl-ß-D-Glucosaminidase, Kidney-Injury-Molecule 1 and Neutrophil Gelatinase-Associated Lipocalin: Long-Term Follow-Up in a Chest Pain Cohort.
Article in Cardiorenal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe goal of the current study was to evaluate the prognostic value of the potential cardiorenal biomarkers kidney injury molecule-1 (u-KIM-1), N-acteyl-ß-D-glucosaminidase (NAG) and urinary neutrophil gelatinase-associated lipocalin (u-NGAL) regarding mortality and major adverse cardiac events (MACEs) in patients presenting with acute chest pain in the emergency department.
methodsThe study cohort consisted of 294 patients who presented themselves with acute chest pain in the emergency department of the university hospital Regensburg. The urinary concentrations of NAG, KIM-1, and NGAL were measured alongside troponin I and NT-proBNP. The patients were followed for 60 months regarding the primary endpoints mortality of any cause and MACEs, consisting of mortality, stroke, congestive heart failure and acute coronary syndrome with the necessity of PCI was gathered (MACE).
resultsFifty four patients died during the follow-up and 97 suffered from MACE. Regarding ROC-analysis NAG as well as u-KIM-1 showed promising predictive values (all-cause mortality: AUC
conclusionUrinary N-acetyl-ß-D-glucosaminidase and, to a lesser extent, kidney injury molecule-1 showed significant value in prediction MACEs and mortality due to any cause in patients with acute chest pain. But the clinical usability is still not certain and further studies are required.
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