Observational studyCritical care explorations2026
Cerebral Venous Sinus Thrombosis in Pediatric Critical Care.
Observational study in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importancePediatric cerebral venous sinus thrombosis (CVST) is being increasingly recognized and can pose substantial risks of morbidity and mortality. Data on the epidemiology, management, and outcomes of CVST in the PICU remain limited.
objectivesTo describe the clinical characteristics, management, and outcomes of critically ill children with CVST during their admission to the PICU. DESIGN, SETTING, AND
participantsWe conducted a retrospective observational cohort study in a quaternary PICU in Toronto, Canada, between 2018 and 2023. Patients 18 years old and younger with acute primary CVST (CVST being the primary indication for ICU admission) and secondary CVST (diagnosis during an admission for an alternative diagnosis) were included in this study. MAIN OUTCOMES AND MEASURES: The primary outcome was in-hospital mortality. Descriptive statistics were used to describe characteristics and outcomes.
resultsThirty patients were admitted with a diagnosis of CVST: 19 (63%) primary, 11 (37%) secondary. Fourteen (47%) had an associated cerebral infarct, and nine (30%) had an associated intracranial hemorrhage. The most common condition associated with secondary CVST was a brain disease requiring neurosurgical intervention (5/11). Five (17%) children with CVST died in this study, of which four had a primary CVST. Children residing in neighborhoods with increased marginalization were disproportionally represented in this cohort. CONCLUSIONS AND RELEVANCE: Primary CVST is more common than secondary and is associated with significant mortality. The disproportionate impact on marginalized children emphasizes the need for heightened awareness and determination of factors associated with this finding.
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