ArticleJournal of neuro-oncology2026
Pseudoprogression in Koos grade 4 vestibular schwannomas following stereotactic radiosurgery: temporal dynamics and radiological predictors.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo gain insight into the volumetric temporal response dynamics following primary stereotactic radiosurgery (SRS) and to evaluate possible MRI-derived predictors at time of treatment for pseudoprogression in sporadic Koos grade 4 vestibular schwannomas (VS).
methodsPatients treated with Gamma Knife radiosurgery for a unilateral sporadic Koos grade 4 VS, larger than 4 cm
resultsA total of 258 patients with a median tumor volume of 6.8 cm
conclusionsPseudoprogression rates in selected Koos grade 4 VS appear comparable to those of smaller tumors. Tumors with microcystic components exhibited significantly lower pseudoprogression rates, which may render them more suitable candidates for SRS. In contrast, macrocystic tumors demonstrated more variable dynamics, warranting careful monitoring in these tumors.
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