Evidence map›Paper›PMID 42184042›Full record

ReviewJournal of cancer research and clinical oncology2026

Molecular mechanisms of 5-FU resistance in colorectal cancer: the regulatory role of lncRNAs.

Bing Bai, Yaqiu Guo, Xiaojun Xie, Changmiao Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cancer research and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bing BaiGeneral Surgery Department, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Yaqiu GuoGeneral Surgery Department, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Xiaojun XieGeneral Surgery Department, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Changmiao WangGeneral Surgery Department, First Affiliated Hospital of Dalian Medical University, Dalian, China. wangcm2617@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are non-coding RNAs (ncRNAs) that serve as key regulators of a variety of biological processes such as tumorigenesis and drug resistance. LncRNAs are more than 200 nucleotides in length and influence cancer progression by acting as miRNA sponges, regulating gene expression and promoting epigenetic changes. In colorectal cancer (CRC), lncRNAs promote 5-fluorouracil (5-FU) resistance by promoting DNA repair, inhibiting apoptosis, enhancing autophagy and epithelial-mesenchymal transition (EMT). Although most lncRNAs are upregulated in drug-resistant CRC cells, some lncRNAs act as inhibitors of tumor resistance. This article provides an overview of lncRNAs that play a role in mediating 5-FU resistance in colorectal cancer and their potential as biomarkers for predicting therapeutic efficacy.

Indexed as

Antimetabolites, AntineoplasticColorectal NeoplasmsDrug Resistance, NeoplasmFluorouracilRNA, Long NoncodingAnimalsEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansAntimetabolites, AntineoplasticFluorouracilRNA, Long Noncoding5-FU resistanceChemotherapy sensitivityColorectal cancerLncRNAMolecular mechanisms

Identifiers

PMID42184042
PMCPMC13388584

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.