Evidence map›Paper›PMID 42184027›Full record

ArticleCellular and molecular life sciences : CMLS2026

cGAMP suppresses FTO expression to promote m

Pan Feng, Xiaolan Chen, Dong Guo, Zhihua Feng, Yajuan Fu, Junzhong Lai, Xiaoyu Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pan Feng *The Cancer Center, Fujian Medical University Union Hospital, Fuzhou, China.
Xiaolan Chen *The Cancer Center, Fujian Medical University Union Hospital, Fuzhou, China.
Dong Guo *Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou, China.
Zhihua FengFuzhou Hospital of Traditional Chinese Medicine, Fuzhou, China.
Yajuan FuFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou, China. fuyajuan@fjnu.edu.cn.
Junzhong LaiThe Cancer Center, Fujian Medical University Union Hospital, Fuzhou, China. laijunzhong@fjmu.edu.cn.
Xiaoyu YangThe School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. xiaoyuyang361@163.com.ORCID http://orcid.org/0000-0002-3855-619X

Funding

Joint Funds for the Innovation of Science and Technology, Fujian Province 2025Y9597Special Subsidy Fund for the Traditional Chinese Medicine of Fuzhou Health Commission, Fujian, China 2025-ZYY-W001
6 · The paper itself

Abstract

Cyclic GMP-AMP (cGAMP) serves as a pivotal second messenger in the cGAS‒STING innate immune signaling pathway and plays a critical role in antiviral and antitumor immunity; however, its regulatory mechanisms governing the epitranscriptome remain to be elucidated. In this study, m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTONucleotides, CyclicAnimalsCell Line, TumorcGAS-STING Signaling PathwayEpitranscriptomeEpitranscriptomicsGene Expression Regulation, NeoplasticHumansImmunity, InnateMiceMice, Inbred C57BLRNA MethylationAlpha-Ketoglutarate-Dependent Dioxygenase FTOcyclic guanosine monophosphate-adenosine monophosphateFTO protein, mouseNucleotides, CycliccGAMPcGAS‒STING pathwayFTOImmunotherapiesN 6-methyladenosine (m⁶A)

Identifiers

PMID42184027
PMCPMC13201664

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.