Evidence map›Paper›PMID 42183937›Full record

ArticleWorld journal of microbiology & biotechnology2026

Synergistic enhancement of industrial adaptability in Lactiplantibacillus plantarum BF_15 through glutathione-mediated redox and DNA repair pathways.

Yalin Liu, Na Zhang, Aixin Guo, Hongjie Liu, Dongyao Li, Chen Li, Hongyan Kang, Hongtao Tian

Abstract read
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In one paragraph

Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yalin Liu *College of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Na Zhang *College of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Aixin GuoCollege of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Hongjie LiuCollege of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Dongyao LiCollege of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Chen LiCollege of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Hongyan KangNew Hope Tensun (Hebei) Dairy Co., Ltd, Baoding, Hebei, 071000, China.
Hongtao TianCollege of Food Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, China. tht631022@163.com.

Funding

Natural Science Foundation of Hebei Province C2023204036Natural Science Foundation of Hebei Province C2023204178
6 · The paper itself

Abstract

The aim of the present study was to improve survival rate of the probiotic strain Lactiplantibacillus plantarum BF_15 during industrial production and storage by supplementing the culture medium with glutathione (GSH). The addition of 3 mM GSH significantly improved the survival rate after freeze-drying (94.45 ± 1.10%), storage at room temperature (74.81 ± 0.19% at 25 ℃ for 8 weeks), and simulated digestion under gastrointestinal conditions (46.03 ± 5.73%) (P < 0.05). GSH supplementation led to an increase in the relative proportion of unsaturated fatty acids in the cell membrane and superoxide dismutase (SOD) activity, while reducing the levels of intracellular reactive oxygen species (ROS). Moreover, GSH supplementation led to an upregulation of four genes related to redox homeostasis and DNA repair (i.e., gshR, LTG66_RS00925, recA, and LTG66_RS14465). These effects established a synergistic GSH-dependent defense network centered on antioxidant metabolism (SOD-GPx-GR system) and DNA protection (RecA-Dps system). Taken together, this study proposes a model for explaining the coordinated mechanisms by which glutathione mediates redox homeostasis and DNA repair in a probiotic strain, providing a sustainable, scalable, and low-carbon preservation strategy suited for industrial application.

Indexed as

DNA RepairGlutathioneLactiplantibacillus plantarumAdaptation, PhysiologicalAntioxidantsCulture MediaIndustrial MicrobiologyMicrobial ViabilityOxidation-ReductionProbioticsReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsCulture MediaGlutathioneReactive Oxygen SpeciesSuperoxide DismutaseAntioxidant capacityFreeze-dryingGSHProbioticStorage

Identifiers

PMID42183937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.