Light-Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction.

Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chuangxin ZhangSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China.

Ruipeng LiSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China.

Yunxia WangSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China.

Feng LiuSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China.ORCID https://orcid.org/0000-0002-0317-3455

Liheng FengSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China.

Funding

Fundamental Research Program of Shanxi Province 202403021224002National Natural Science Foundation of China 22177065National Natural Science Foundation of China 22375119National Natural Science Foundation of China U21A6004

6 · The paper itself

Abstract

Developing long-wavelength-activated nitric oxide (NO) donors has attracted increasing attention for achieving precise photo-controlled NO release with deep tissue penetration and minimal phototoxicity, yet this remains a major challenge. Herein, we report a deep-red light-triggered NO-releasing molecule (DBTBT-NO) via a novel photoexcitation-mediated electron transfer process to induce abundant peroxynitrite generation. The DBTBT-NO can be activated by deep-red light to release NO, which is facilitated by photoinduced intramolecular charge separation. Meanwhile, superoxide anions generated during photolysis rapidly react with NO to produce massive peroxynitrite in mitochondria, which induces tumor cell pyroptosis at a low light dose of 15 J/cm

Indexed as

Nitric OxideNitric Oxide DonorsPyroptosisAnimalsCell Line, TumorElectron TransportHumansMicePeroxynitrous AcidPhotolysisRed LightNitric OxideNitric Oxide DonorsPeroxynitrous Acidintramolecular electron transfernitric oxide releaseperoxynitrite generationphotocatalysispyroptosis

Identifiers

PMID42183842

DOI10.1002/advs.202522486

PMCPMC13335896

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.