ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Spontaneous Non-Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions. From an engineering perspective, these molecular reactions and interactions can be exploited for disease diagnosis, therapeutic interventions, and a variety of biomedical applications. In this review, we summarize non-catalyzed molecular reactions and interactions that occur spontaneously under physiological conditions without enzymatic mediation. We discuss their biomedical implications in disease diagnosis, drug delivery, and biomaterials for regenerative and cellular engineering. Looking forward, we highlight emerging opportunities to leverage these spontaneous non-catalyzed reactions and interactions in drug design, nonenzymatic activation of genome editing in synthetic biology, and non-genetic surface modification and activation of immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.