Evidence map›Paper›PMID 42183674›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Tailored Nanogel Network Topology Enables Clinical Ultrasound-Induced Mechanochemical Activation for In Vivo Therapy.

Helin Li, Fangyin Song, Xiaoye Hu, Li Jing, Qi Shuai, Weike Su, Andrij Pich, Xin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helin LiCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Fangyin SongCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Xiaoye HuDepartment of Medical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Li JingHepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, School of Medicine, Zhejiang University, Hangzhou, China.
Qi ShuaiCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.ORCID 0000-0002-6496-172X
Weike SuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Andrij PichDWI-Leibniz-Institute for Interactive Materials, Aachen, Germany.ORCID 0000-0003-1825-7798
Xin LiState Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-7837-7874

Funding

Deutsche ForschungsgemeinschaftNational Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province LTGY23B040001NSFC Excellent Senior Scientist Program 52350710203NSFC Excellent Young Scientists Fund Program (overseas)
6 · The paper itself

Abstract

Polymer mechanochemistry enables the selective mechanophore activation for precise molecular release. However, this field has long relied on the strong cavitation effects of low-frequency ultrasound, which are incompatible with clinically high-frequency ultrasound (> 1 MHz), hindering its biomedical applications. Herein, we report a nanogel network topology-programmed mechanochemical strategy, enabling iterative activation of mechanophores under high-frequency (up to 2.4 MHz) and low-intensity (down to 2 W/cm

Indexed as

DoxorubicinNanogelsUltrasonic WavesAnimalsHumansMicePolyethylene GlycolsPolyethyleneimineDoxorubicinNanogelspolyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneiminehigh‐frequency ultrasoundnanogelsnetwork topologypolymer mechanochemistrytumor therapy

Identifiers

PMID42183674
PMCPMC13382917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.