ArticleSchizophrenia bulletin open2026
Do Obsessive-Compulsive Symptoms Increase the Risk of Developing Psychosis? A Systematic Review and Meta-analysis.
Article in Schizophrenia bulletin open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Hypothesis: There is a phenomenological overlap of obsessive-compulsive symptoms (OCSs) and psychosis, leading to discussion about whether OCSs increase the risk of developing psychosis. Previous reviews have focused on clinical high-risk (CHR) cohorts, which may misestimate risk due to sampling biases. The current systematic review and meta-analyses aimed to determine the risk of OCSs on developing psychosis in individuals classified at CHR and at the population level. Study Design: A total of 2081 articles were screened, with 11 studies meeting the criteria for inclusion. Two separate meta-analyses were conducted for CHR cohorts and for register-based cohorts to estimate the risk ratio (RR) of OCSs for developing psychosis. Study Results: In CHR cohorts, the meta-analysis found no significant difference in the risk of developing psychosis between individuals with and without OCSs (RR = 0.99, 95% CI, 0.71-1.38, Conclusions: The limited number of studies and high heterogeneity in the population-level cohort limit any firm conclusions. However, the findings indicate that OCSs may increase the risk of developing psychosis in the register-based cohorts, but not in CHR cohorts. The discrepancy may reflect shared underlying vulnerabilities present in both OCSs and psychosis that are obscured by samples enriched for psychosis risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.