Evidence map›Paper›PMID 42183379›Full record

ArticleResearch square2026

Astrocytic but not Microglial Antigen Presentation Shapes Protective Immunity to Toxoplasma gondii in the Brain.

Sydney A Labuzan, Anne E Schuster, Michael A Kovacs, Maureen N Cowan, Mark J Lawson, Isaac W Babcock, Lydia A Sibley, Abigail G Kelly, Anne E Marchildon, Tajie H Harris

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sydney A LabuzanUniversity of Virginia.
Anne E SchusterUniversity of Virginia.
Michael A KovacsUniversity of Virginia.
Maureen N CowanUniversity of Virginia.
Mark J LawsonUniversity of Virginia.
Isaac W BabcockUniversity of Virginia.
Lydia A SibleyUniversity of Virginia.
Abigail G KellyUniversity of Virginia.
Anne E MarchildonUniversity of Virginia.
Tajie H HarrisUniversity of Virginia.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
BIOTECHNOLOGY TRAINING PROGRAMT32GM008715 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LAURIE, GORDON WILLIAM · 2000 to 2019
$6.6M
Alarmin-mediated control of CNS infectionR01NS112516 · NINDS · UNIVERSITY OF VIRGINIA · PI HARRIS, TAJIE H. · 2020 to 2023
$1.9M
Caspase-8 mediated control of CNS infectionR01NS134747 · NINDS · UNIVERSITY OF VIRGINIA · PI TAJIE H. HARRIS · 2024 to 2026
$1.5M
Brain, Immunology and Glia Training ProgramT32NS115657 · NINDS · UNIVERSITY OF VIRGINIA · PI Alban P Gaultier, TAJIE H. HARRIS · 2021 to 2026
$1.2M
The role of meningeal lymphatic vasculature in regulating immunity and intracranial pressure during central nervous system infectionF30AI154740 · NIAID · UNIVERSITY OF VIRGINIA · PI KOVACS, MICHAEL · 2021 to 2021
$51k
NIAID NIH HHS F30 AI154740NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI007496NIGMS NIH HHS T32 GM007267NIGMS NIH HHS T32 GM008715NINDS NIH HHS R01 NS112516NINDS NIH HHS R01 NS134747NINDS NIH HHS T32 NS115657
6 · The paper itself

Abstract

T cells play a pivotal role in orchestrating immune defense within the central nervous system (CNS) during many infections.

Indexed as

Antigen PresentationAstrocytesMicrogliaNeuroimmunologyToxoplasma gondii

Identifiers

PMID42183379
PMCPMC13193102

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.