Evidence map›Paper›PMID 42183291›Full record

ArticleFrontiers in immunology2026

IgA nephropathy-associated breast milk B cell alterations.

Katerina Zachova, Alica Cutkova, Petr Kosztyu, Yukako Ohyama, Kazuo Takahashi, Josef Zadrazil, Jiri Orsag, Nadezda Petejova, Jiri Mestecky, Milan Raska

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katerina ZachovaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.
Alica CutkovaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.
Petr KosztyuDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.
Yukako OhyamaDepartment of Biomedical Molecular Sciences, School of Medicine, Fujita Health University, Nagoya, Japan.
Kazuo TakahashiDepartment of Biomedical Molecular Sciences, School of Medicine, Fujita Health University, Nagoya, Japan.
Josef ZadrazilDepartment of Internal Medicine III Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Olomouc, Czechia.
Jiri OrsagDepartment of Internal Medicine III Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Olomouc, Czechia.
Nadezda PetejovaDepartment of Internal Medicine III Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.
Jiri MesteckyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Milan RaskaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: IgA nephropathy (IgAN) is a mucosal immune-associated disease characterized by the overproduction of galactose-deficient IgA1 (Gd-IgA1) and formation of nephritogenic immune complexes. Epstein-Barr virus (EBV), which preferentially infects IgA Methods: We performed a phenotypic analysis of B cells (CD19 Results: Breast milk from mothers with IgAN contains a significantly higher proportion of EBER Conclusion: Despite the limited number of analyzed samples, we detected interesting differences in B cells in the breast milk of IgAN mothers and HC. The analysis of B cell populations in the breast milk of IgAN mothers indicates EBV-associated B cell dysregulation. The enrichment of EBV

Indexed as

B-LymphocytesGlomerulonephritis, IGAMilk, HumanAdultCell DifferentiationEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansImmunoglobulin APlasma CellsSyndecan-1Immunoglobulin ASyndecan-1B cellsbreast milkEpstein–Barr virusgalactose deficient IgA1IgA nephropathymigrating pre-plasma cellsmucosal immunity

Identifiers

PMID42183291
PMCPMC13194096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.