ArticleFrontiers in immunology2026
Hyperglycemia- induced innate immune tolerance involves the metabolic and epigenetic rewiring in human alveolar macrophages.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Introduction: Diabetic patients have increased susceptibility to pulmonary infections. However, whether hyperglycemia contributes to this susceptibility via the immune memory of alveolar macrophages (AMs) remains unclear. Methods: Primary human AMs from patients with diabetes were isolated. An Results: AMs exposed to hyperglycemia, either Discussion: Hyperglycemia induces immune tolerance in human AMs through metabolic reprogramming (impaired fatty acid oxidation, lipid dysregulation) and epigenetic modifications at regulatory regions of autophagy and apoptosis-related genes. These findings suggest a potential mechanistic link between hyperglycemia and increased pulmonary infection susceptibility in diabetic patients, and identify candidate immunomodulatory targets for further investigation.
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