Evidence map›Paper›PMID 42183266›Full record

ArticleFrontiers in immunology2026

The risk of venous thromboembolism in kidney transplant recipients is enhanced following a cytomegalovirus infection.

Christophe Masset, Marine Lorent, Florent Le Borgne, Anne Scemla, Clarisse Kerleau, Celine Bressollette-Bodin, Emmanuel Morelon, Xavier Charmetant, Moglie Lequintrec-Donnette, Vincent Pernin and 12 more

Abstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Christophe MassetInstitut de Transplantation Urologie Néphrologie (ITUN), Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.
Marine LorentInstitut de Transplantation Urologie Néphrologie (ITUN), Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.
Florent Le BorgneINSERM UMR 1246 - SPHERE, Nantes Université, Tours Université, Nantes, France.
Anne ScemlaService de Néphrologie - Transplantation rénale Adulte, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes Sorbonne Paris Cité, Paris, France.
Clarisse KerleauInstitut de Transplantation Urologie Néphrologie (ITUN), Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.
Celine Bressollette-BodinCenter for Research in Transplantation and Translational Immunology, Nantes Université, INSERM, UMR 1064, Nantes, France.
Emmanuel MorelonHospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie Clinique, Lyon, France.
Xavier CharmetantHospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie Clinique, Lyon, France.
Moglie Lequintrec-DonnetteDepartment of Nephrology and Renal Transplantation, Lapeyronnie Hospital and INSERM U1183, Institute of Regenerative Medicine and Biotherapies, Montpellier, France.
Vincent PerninDepartment of Nephrology and Renal Transplantation, Lapeyronnie Hospital and INSERM U1183, Institute of Regenerative Medicine and Biotherapies, Montpellier, France.
Marc LadrièreRenal Transplantation Department, Brabois University Hospital, Nancy, France.
Sophie GirerdRenal Transplantation Department, Brabois University Hospital, Nancy, France.
Olivier AubertINSERM UMR 1246 - SPHERE, Nantes Université, Tours Université, Nantes, France.
Christophe LegendreINSERM UMR 1246 - SPHERE, Nantes Université, Tours Université, Nantes, France.
Antoine SicardNephrology, Dialysis and Transplantation Department, Pasteur 2 Hospital, Nice University Hospital, Nice, France.
Laetitia AlbanoNephrology, Dialysis and Transplantation Department, Pasteur 2 Hospital, Nice University Hospital, Nice, France.
Carmen LefaucheurDepartment of Nephrology and Kidney Transplantation, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Gillian DivardDepartment of Nephrology and Kidney Transplantation, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Christophe MariatService de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, Saint Etienne, France.
Guillaume ClaisseService de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, Centre Hospitalier Universitaire (CHU) de Saint-Etienne, Saint Etienne, France.
Jacques DantalInstitut de Transplantation Urologie Néphrologie (ITUN), Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.
Magali GiralInstitut de Transplantation Urologie Néphrologie (ITUN), Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In immunocompetent individuals, past CMV infection has been linked to venous thromboembolism (VTE) risk, but evidence remains inconclusive due to timing of serologic diagnosis. Data in immunocompromised patients are scarce. We therefore assessed VTE risk following CMV viremia in kidney transplant recipients (KTRs). Methods: We conducted a multicenter cohort study of 15, 433 KTRs transplanted between 2000 and 2021, among whom 1, 756 developed CMV infection, with a 2-year cumulative incidence of 13% (95% CI: 12.4-13.5%). VTE occurred in 6.7% of KTRs (95% CI: 6.3-7.1%). Results: Using time-varying Cox models stratified on centers and transplant period, asymptomatic CMV viremia (considered as a time-dependent parameter) was significantly associated with an increased VTE risk (HR = 1.61, 95% CI: 1.19-2.17), with a higher risk after symptomatic CMV disease (HR = 2.00, 95% CI: 1.32-3.02), after adjustment for confounders. The risk was similar following primary infection or a reactivation of latent CMV. Conclusion: In conclusion, CMV viremia, especially symptomatic disease, was associated to a higher risk of VTE in KTRs. Given the frequency of CMV post-transplant, clinicians should be aware of this association for prompt diagnosis and management.

Indexed as

CytomegalovirusCytomegalovirus InfectionsKidney TransplantationVenous ThromboembolismAdultAgedFemaleHumansIncidenceMaleMiddle AgedPostoperative ComplicationsRisk FactorsTransplant RecipientsViremiaCMVimmunothrombosiskidney transplantationpancreas - kidney transplantationthrombosis

Identifiers

PMID42183266
PMCPMC13194019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.