ArticleFrontiers in immunology2026
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Testosterone Modulates Virulence-Associated Phenotypes ofPathogens (Basel, Switzerland) · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Periodontitis is a risk factor for adverse pregnancy outcomes, yet the mechanisms linking Methods: First-trimester trophoblast cell line was exposed to PgOMV, and conditioned media were used to evaluate monocyte migration and dendritic cell differentiation Results: PgOMV priming increased granulocyte-macrophage colony-stimulating factor and C-C motif chemokine ligand 2 expression and enhanced monocyte migration. While Tb CM impaired monocyte-to-dendritic cell differentiation and promoted a tolerogenic phenotype characterized by low CD86 expression, increased interleukin-10 production and a higher IL-10/TNF-α ratio, PgOMV exposure abrogated this regulatory program and restored inflammatory maturation, including responsiveness to lipopolysaccharide. Discussion: These findings demonstrate that PgOMV reprogram trophoblast secretory activity, disrupt tolerogenic dendritic cell differentiation and provide a mechanistic link between periodontal infection and impaired immune regulation during pregnancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.