ArticleFrontiers in immunology2026
The pathological Huntingtin CAG triplet expansion differentially affects the diagnosis of systemic and organ-specific autoimmune diseases.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In Huntington's disease (HD), signs of inflammatory activation are found in the brain, cerebrospinal fluid, and blood. HD monocytes are reported to be hyperreactive Aim: To explore the frequency of autoimmune diseases (AIDs) in HD mutation carriers (people with the HD mutation, PwHD) compared to control participants (CPs) as markers of immune dysfunction related to CAG triplet expansion in the Huntingtin ( Methods: Analysis of the Enroll-HD periodic dataset #5 (European sites) was conducted. Definite AIDs, coded using the abbreviated ICD-10 in the dataset for comorbidities, were identified. AIDs were grouped by organ specificity into arthropathy-dominant AIDs of musculoskeletal and connective tissues (arthropathic), as well as endocrine, dermatological, and gastrointestinal AIDs. Results: Although AID frequency was not different in PwHD (709/10,594; 6.7%) compared to CPs (176/2,477; 7.1%, Conclusion: Both the presence and the exact size of the pathological CAG triplet expansion in the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.