Evidence map›Paper›PMID 42183189›Full record

ReviewFrontiers in immunology2026

Immunoscore and beyond: evolution and clinical integration of immune contexture-based biomarkers across solid tumours.

Esteban Orenes-Piñero, Silverio Ros-Martínez, José Luis Alonso-Romero, Juan Antonio Ortega-García

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Esteban Orenes-PiñeroDepartment of Biochemistry and Molecular Biology, University of Murcia, Murcia, Spain.
Silverio Ros-MartínezDepartment of Oncology, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Murcia, Spain.
José Luis Alonso-RomeroDepartment of Oncology, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Murcia, Spain.
Juan Antonio Ortega-GarcíaPaediatric Environmental Health Specialty Unit, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumour immune microenvironment is increasingly recognised as a critical determinant of cancer progression, prognosis, and therapeutic response, challenging the sufficiency of anatomy-based staging systems such as TNM. The Immunoscore (IS), originally validated in colorectal cancer, provides a standardised, spatially resolved assessment of CD3

Indexed as

Biomarkers, TumorLymphocytes, Tumor-InfiltratingNeoplasmsTumor MicroenvironmentAnimalsHumansNeoplasm StagingPrognosisBiomarkers, Tumorbladder cancergastric cancerhead and neck squamous cell carcinomahepatocellular carcinomaImmunoscoremelanomanon-small cell lung cancer

Identifiers

PMID42183189
PMCPMC13194529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.