Evidence map›Paper›PMID 42183181›Full record

ArticleAtherosclerosis plus2026

Environmental pollution, apolipoprotein A-1 autoantibodies and cardiovascular risk: evidence from a geospatial cross-sectional study.

Noé Fellay, Sabrina Pagano, Pedro Marques-Vidal, Peter Vollenweider, Silvia Stringhini, David De Ridder, Julien Vaucher, Aurelien Thomas, David Carballo, Idris Guessous and 3 more

Abstract read
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In one paragraph

Article in Atherosclerosis plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Noé FellayGeospatial Molecular Epidemiology Group (GEOME), Laboratory for Biological Geochemistry (LGB), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Sabrina PaganoDivision of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, 1205, Geneva, Switzerland.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Silvia StringhiniDepartment of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
David De RidderDepartment of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Julien VaucherDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Aurelien ThomasUnit of Forensic Toxicology and Chemistry, CURML, Lausanne and Geneva University Hospitals, Lausanne, Geneva, Switzerland.
David CarballoDivision of Cardiology, Department of Medicine, Geneva University Hospitals, Switzerland.
Idris GuessousDepartment of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Mayssam NehmeDepartment of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Stéphane JoostGeospatial Molecular Epidemiology Group (GEOME), Laboratory for Biological Geochemistry (LGB), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Nicolas VuilleumierDivision of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, 1205, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Autoantibodies against apolipoprotein A-1 (AAA1) are independent cardiovascular risk factor in the general population. Genetic factors and viral infections have been linked to AAA1 occurrence. We studied the association between environmental pollution and AAA1 response and their relationship with years of life lost or gained (YPLLG). Methods: We conducted a cross-sectional study involving 1867 individuals recruited between 2016 and 2018 in Geneva, Switzerland, characterized for serum AAA1 levels. Exploratory and confirmatory geospatial analyses of AAA1, air pollution (NO Results: Significant geographic clustering of high AAA1 serum levels (hotspots) were identified in urban areas with heavy traffic, associated with higher air pollutant levels (median NO Conclusions: While causal inference cannot be drawn due to the cross-sectional design, AAA1 hotspots overlapped regions of higher air and soil pollution and reduced life expectancy. Determining causality and whether specific pollutants amplify the AAA1 response will be key to validate these hypothesis-generating findings.

Indexed as

Apolipoprotein A-1AutoantibodiesCardiovascular diseasesEnvironmental pollutionLife expectancySpatial analysis

Identifiers

PMID42183181
PMCPMC13195344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.