ArticleInternational journal of genomics2026
PSIP1 Orchestrates Immune Escape in Osteosarcoma: Insights From Single-Cell Analysis and Implications for Immunotherapy Resistance.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- PSIP1 Orchestrates Immune Escape in Osteosarcoma: Insights From Single-Cell Analysis and Implications for Immunotherapy Resistance.International journal of genomics · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteosarcoma (OS) is characterized by a highly heterogeneous tumor microenvironment (TME) that frequently limits the efficacy of immunotherapy. Identifying molecular drivers of immune escape (IE) is essential for improving therapeutic outcomes. Methods: We integrated single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data to dissect the OS immune landscape. Utilizing high-dimensional weighted gene coexpression network analysis (hdWGCNA), we identified gene modules specifically associated with IE. Results: Within the IE-related module, PSIP1 emerged as the most significant prognostic hub gene. ScRNA-seq analysis localized PSIP1 primarily to malignant cell populations. High PSIP1 expression consistently correlated with abbreviated overall survival across multiple independent cohorts. Functional enrichment and GSEA revealed that PSIP1 is intrinsically linked to the suppression of critical immune effectors, including B-cell signaling, lymphocyte chemotaxis, and NK cell-mediated cytotoxicity. Crucially, PSIP1 exhibited robust predictive performance for immunotherapy response; elevated PSIP1 levels were associated with diminished activity of multiple established immune-response signatures and poor survival in patients undergoing checkpoint blockade. Conclusion: Our study positions PSIP1 as a novel orchestrator of immune evasion and a promising predictive biomarker for immunotherapy resistance in OS, offering a potential target to overcome therapeutic recalcitrance.
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Registered trials
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