Evidence map›Paper›PMID 42183170›Full record

ArticleInternet interventions2026

Cognitive control training as an add-on treatment for late-life depression: A multicenter randomized controlled trial.

Yannick Vander Zwalmen, Janna N Vrijsen, Bart Meuleman, Marie-Anne Vanderhasselt, Paul Naarding, Rose M Collard, Marleen van Beek, Peter Oostelbos, Linda Bolier, Dorine van Driel and 2 more

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Article in Internet interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yannick Vander ZwalmenDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Janna N VrijsenDonders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Radboud university medical center, Nijmegen, the Netherlands.
Bart MeulemanBehavioural Science Institute, Radboud University, Nijmegen, the Netherlands.
Marie-Anne VanderhasseltDepartment of Head and Skin, Ghent University, Ghent, Belgium.
Paul NaardingDepartment of Old-age Psychiatry, GGNet Mental Health, Apeldoorn, the Netherlands.
Rose M CollardDepartment of Psychiatry, Radboud university medical center, Nijmegen, the Netherlands.
Marleen van BeekDonders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Radboud university medical center, Nijmegen, the Netherlands.
Peter OostelbosDepression Association, Utrecht, the Netherlands.
Linda BolierTrimbos Institute, Utrecht, the Netherlands.
Dorine van DrielSeniorBeter, Nijmegen, the Netherlands.
Jan SpijkerBehavioural Science Institute, Radboud University, Nijmegen, the Netherlands.
Eni S BeckerBehavioural Science Institute, Radboud University, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Late-life depression (LLD) is a prevalent and debilitating condition associated with a poor long-term prognosis and high rates of chronicity. Cognitive control impairments are common in LLD and contribute to symptom persistence, yet they are not sufficiently targeted by standard treatments. We investigated whether adding a brief Cognitive Control Training (CCT) program to treatment as usual (TAU) improved outcomes in older adults with LLD. Methods: In this multicenter, single blind randomized controlled trial, 90 older adults diagnosed with LLD were randomized to eight sessions of CCT ( Results: A mixed-effects model revealed no significant difference in the reduction of depressive symptoms between the CCT and ACT conditions over the twelve-month follow-up period. Both conditions improved on symptom severity, but no significant differences were found for any of the secondary outcomes. Discussion: Contrary to our hypothesis, CCT did not yield more clinical improvement in depressive or cognitive outcomes in older adults. Potential explanations include suboptimal intervention dose/intensity, age-related reductions in neural plasticity and processing speed that may limit trainability, and high baseline severity and multimorbidity typical of specialized care. Conclusion: In this multicenter trial, adding CCT to TAU did not confer clinical benefits for late-life depression. Future research should investigate different dosage strategies and identify patient subgroups most likely to benefit.

Indexed as

Cognitive controlCognitive control trainingDepressionLate-life depressionWorking memory training

Identifiers

PMID42183170
PMCPMC13197806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.