Evidence map›Paper›PMID 42183153›Full record

ArticleCell biomaterials2026

Mapping cellular and ECM heterogeneity in pulmonary fibrosis - insights from recent spatiomics studies.

Mahsa Yazdani, Li Wang, Qiyue Ding, Negin Frazad, Mingyu Yang, Shriramprasad Venkatesan, Michal Stachowiak, Laertis Ikonomou, Ya-Wen Chen, Rong Fan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mahsa YazdaniDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA 14260.
Li WangDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA 14260.
Qiyue DingDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA 14260.
Negin FrazadDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA 06520.
Mingyu YangDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA 06520.
Shriramprasad VenkatesanVersiti Blood Research Institute, Milwaukee, Wisconsin 53226.
Michal StachowiakDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA 14260.
Laertis IkonomouDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA 14260.
Ya-Wen ChenDepartment of Otolaryngology, Department of Stem Cell Biology and Regenerative Medicine, Institute for Airway Sciences, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Rong FanDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA 06520.
Yang LiuDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA 06520.
Ruogang ZhaoDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA 14260.

Funding

Gene regulatory networks in early lung epithelial cell fate decisionsR01HL158965 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Laertis Ikonomou · 2023 to 2026
$2.5M
Mechanoimmunological interactions between TCR-T cells and tumor fibrotic microenvironmentR01CA273929 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Richard C Koya, Ruogang Zhao · 2023 to 2026
$2.0M
Modeling pulmonary fibrosis progression caused by differential mechanical stretchR01HL163428 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ZHAO, RUOGANG · 2022 to 2025
$1.6M
NCI NIH HHS R01 CA273929NHLBI NIH HHS R01 HL158965NHLBI NIH HHS R01 HL163428
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) features spatially heterogeneous tissue remodeling, with fibroblast foci (FF) acting as central hubs of fibrogenesis at the interface between remodeled and preserved alveolar regions. Emerging spatiomics studies reveal that FF comprise distinct functional zones-an activated fibroblast core, a transitional front, and surrounding mature fibrosis-each defined by unique cellular and molecular programs. Spatially resolved profiling has uncovered diverse fibroblast subpopulations, epithelial injury states, macrophage niches, and cell-matrix signaling circuits that together shape the fibrotic niche. By linking gene and protein expression to tissue architecture, spatiomics clarifies how fibroblast activation, epithelial remodeling, and ECM reorganization integrate across space to drive irreversible scarring. This Perspective summarizes spatiomics approaches in pulmonary fibrosis, synthesizes the key biological insights they have revealed, and highlights emerging opportunities-spanning integrative multiomics, AI-guided inference, and organoid models-to advance mechanistic understanding and therapeutic discovery in IPF.

Identifiers

PMID42183153
PMCPMC13197085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.