Can cytology accurately predict the malignancy of feline mammary gland tumours?

PICO question: In cats with mammary gland tumours, is cytology compared to histopathology an accurate method for predicting the malignancy of the tumour? Clinical bottom line: Category of research: Diagnosis. Number and type of study designs reviewed: One case series and two diagnostic accuracy studies. Strength of evidence: Moderate. Outcomes reported: In cats with mammary gland tumours, cytology can reliably predict the malignancy of the tumour when compared to histopathology as the clinical reference standard. Conclusion: There is moderate evidence to show that the diagnostic accuracy of cytology in predicting the malignancy of feline mammary gland tumours is high, especially in terms of sensitivity, but further research is needed to confirm its specificity. Due to the current uncertainties, all preoperative cytological diagnoses should be confirmed with a postoperative histopathological examination. How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient's circumstances and owners' values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.