ArticleFrontiers in bioengineering and biotechnology2026
Linking layered corneal compactness to macroscopic biomechanics:
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate Design: Cross-sectional study. Methods: In the study, a total of 221 eyes from 221 healthy participants were enrolled. Corneal deformation properties were measured by the air-puff Corvis ST. Scheimpflug images of the cornea were captured to examine 50-sublayer densitometry values using the caliper technique. According to the spatial patterns of corneal densitometry with depth, the whole cornea was then divided into multiple layers. Different layers were corresponding to different corneal structures (epithelium, Bowman membrane, anterior, middle, and posterior stroma, Descemet membrane, and, endothelium). In each layer, 19 predetermined data point (1, 6, 12 points on the central, paracentral, and peripheral zones, respectively) were taken out for analysis. Results: Layered densitometry analysis revealed distinct structural compactness patterns across seven corneal layers (epithelium to endothelium). Significant correlations emerged between densitometry values and dynamic biomechanical parameters, exhibiting strong layer-specific and regional dependencies. The anterior cornea (Bowman's membrane and anterior stroma) showed the most robust associations: increased densitometry in these layers correlated positively with stiffness parameters (SPA1 [stiffness parameter in the first applanation], SPHC [stiffness parameter highest concavity]; central SPHC r = 0.3, Conclusion: The study established the
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