ArticleBrain communications2026
Microstructural alterations of parafascicular nucleus pathways associated with freezing of gait in Parkinson's disease.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The parafascicular nucleus (Pf) projects to the dorsal putamen (Dpu), subthalamic nucleus (STN) and nucleus accumbens (Nac), regions implicated in both motor and non-motor symptoms of Parkinson's disease. However, microstructural alterations of these pathways across different Parkinson's disease motor subtypes remain unclear and heterogeneity within the postural instability and gait disorder (PIGD) subtype, particularly with respect to the presence or absence of freezing of gait (FOG), has often been overlooked. Therefore, this study employed diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to examine microstructural properties of Pf projections in patients with tremor-dominant Parkinson's disease (PDTD;
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