Long-term postdischarge immunonutrition management in elective colorectal cancer surgery patients an interim analysis of a Chinese multicenter randomised controlled trial.

Mandula Bao, Fei Huang, Pu Cheng, Zhaoxu Zheng

Abstract read

In one paragraph

Article in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Mandula BaoDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Fei HuangDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Pu ChengDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Zhaoxu ZhengDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative malnutrition is prevalent in cancer patients, and enteral nutrition improves short-term outcomes. However, long-term data on post-discharge immunonutrition (IMN) effects on nutritional and immune status in colorectal cancer (CRC) patients after radical surgery are limited. Multicenter, randomized controlled trial (ChiCTR2300071078) across 20 Chinese centers. Screened CRC patients were randomized (2:1) to 30-day post-discharge oral IMN (IMPACT Oral®) or standard nutrition. Primary endpoint: change in prealbumin (ΔPA). Secondary endpoints: changes in albumin, transferrin, BMI, PG-SGA, glucose, lymphocyte count, and immunoglobulins (IgG, IgM, IgA). Interim analysis included 563 patients (373 IMN, 190 control; similar demographics). Compared with controls, the IMN group showed significantly greater ΔPA, reduced ΔPG-SGA, and increased Δlymphocyte count, ΔIgG, and ΔIgM (all P < 0.05), indicating sustained improvement in nutritional and immune status. Long-term post-discharge oral IMN enhances nutritional status and immune response in CRC patients following radical surgery. Registry: www.chictr.org.cn. TRN: ChiCTR2300071078. Registration date: 4 May 2023.

Indexed as

Colorectal cancerImmunonutritionPostoperative interventionRandomized controlled trialSurgery

Identifiers

PMID42183029

DOI10.1016/j.metop.2026.100471

PMCPMC13196534

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.