ArticleHeart rhythm O22026
Fetal heart rate and the neonatal QT interval: Results from a large general population study.
Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fetal bradycardia has been reported in neonates with congenital long QT syndrome, but it remains unknown whether there is a general association between fetal heart rate (FHR) and the neonatal QT interval. Objective: We examined whether first- (FHR1) and second-trimester FHR (FHR2) measurements were associated with the neonatal QT interval. Methods: We investigated neonates from a large population-based cohort study with available electrocardiograms and FHR1 measurements. We also investigated a subgroup with FHR2 data. The neonatal corrected QT (QTc) interval was the primary outcome variable. Univariate and multiple regression analyses were also performed. Results: The study cohort included 7998 neonates (48.4% girls) with a median age of 11 days (interquartile range [IQR] 7-14) at electrocardiographic recording. At a median gestation age (GA) of 90 days, we found a median FHR1 of 159 beats per minute (IQR 155-164) and no association with the QTc interval (adjusted difference 0.407 × 10 Conclusion: FHR2 is associated with longer neonatal QTc interval, whereas no association was observed between FHR1 and the QTc interval. These findings suggest a GA-dependent association, emphasizing the importance of considering GA when evaluating FHR and neonatal QT intervals.
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