Combined supplementation with isochlorogenic acid and quercetagetin ameliorates dexamethasone-induced intestinal injury via attenuation of oxidative stress and inflammation.

Xiaoning Li, Yilin Feng, Songkang Bai, Pengyu Zhao, Ruihui Dai, Ning Li

Abstract read

In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Xiaoning LiDepartment of Science and Engineering, Hebei Agricultural University, Cangzhou, China.

Yilin FengDepartment of Science and Engineering, Hebei Agricultural University, Cangzhou, China.

Songkang BaiDepartment of Science and Engineering, Hebei Agricultural University, Cangzhou, China.

Pengyu ZhaoHebei Province Plant Source Animal Health Products Technology Innovation Center, Handan, China.

Ruihui DaiDepartment of Science and Engineering, Hebei Agricultural University, Cangzhou, China.

Ning LiOffice of Development and Planning, Hebei Agricultural University, Baoding, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a critical factor impairing intestinal function and homeostasis in broilers, particularly under dexamethasone (DEX)-induced conditions. Isochlorogenic acid (ICA) and quercetagetin (QG) are natural flavonoids with known antioxidant properties, but their combined effects remain unclear. A total of 270 one-day-old Arbor Acres broilers were randomly assigned to three groups: control, DEX-induced injury, and ICA+QG treatment (100 mg/kg each). After 21 days of feeding, oxidative stress was induced by intraperitoneal injection of DEX (3 mg/kg). Serum antioxidant indices, immune parameters, intestinal morphology, and gut microbiota composition were analyzed. Compared with the DEX group, ICA+QG supplementation significantly increased serum superoxide dismutase (SOD) and glutathione (GSH) activities (

Indexed as

antioxidantimmune performanceisochlorogenic acidmicrobial diversityquercetagetin

Identifiers

PMID42182926

DOI10.3389/fvets.2026.1797403

PMCPMC13192374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.