ArticleFrontiers in veterinary science2026
Schisandrin B alleviates high-glucose diet-induced oxidative stress, inflammation, and tissue injury in zebrafish and is associated with alterations in intestinal microbiota.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
High-glucose diet (HGD) has been reported to alter gut microbiota and induce chronic inflammation and oxidative stress. In this study, we demonstrated that Schisandrin B (SchB) markedly attenuated HGD-induced physiological disturbances in zebrafish, with a focus on multiple tissues, including the liver, intestine, brain, and retina. The results showed that SchB attenuated oxidative stress, inflammatory responses, and tissue injury induced by HGD. SchB was associated with reduced levels of reactive oxygen species (ROS) and malondialdehyde (MDA) levels, as well as enhanced superoxide dismutase (SOD) activity. In addition, the mRNA expression levels of oxidative stress-related genes (Nrf2 and HO-1) and inflammatory markers (IL-1β, IL-8, TNF-
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