Evidence map›Paper›PMID 42182880›Full record

ArticleMaterials today. Bio2026

Breaking the vicious cycle of diabetic wounds with an exosome-engineered dual-responsive microneedle patch.

Xinyu Gu, Shen Shen, Qingmiao Shi, Ziyi Xu, Minghang Zhang, Lifan Zhang, Chen Xue, Yuting He, Juan Lu, Li Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyu GuHenan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, 471003, China.
Shen ShenDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 410052, China.
Qingmiao ShiDepartment of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, 471003, China.
Ziyi XuHenan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, 471003, China.
Minghang ZhangHenan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, 471003, China.
Lifan ZhangHenan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, 471003, China.
Chen XueDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 410052, China.
Yuting HeDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 410052, China.
Juan LuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Li LiDepartment of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wound (DW), a prevalent type of chronic non-healing injury, poses substantial clinical challenges owing to persistent oxidative stress, dysregulated inflammation and recurrent bacterial infections. To rationally modulate the microenvironment of DWs, this study fabricated a core-shell structured multifunctional microneedle (MN) patch, designated as AEP-GCMN. Specifically, we designed engineered exosomes, Aloe-Exo

Indexed as

Anti-inflammationDiabetic woundsExosomesMicroneedles

Identifiers

PMID42182880
PMCPMC13191656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.