Evidence map›Paper›PMID 42182871›Full record

ArticleMaterials today. Bio2026

Spermine oxidase-DOX conjugates reshape tumor microenvironment via carbonyl stress to potentiate bladder cancer chemotherapy.

Yingying Xu, Chengyang Zhao, Shuai Fu, Yaohai Wu, Yingzhao Shao, Dongchen Li, Yingwen Wang, Lingchang Zhang, Aijing Zhang, Yuxiang Meng and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yingying XuDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Chengyang ZhaoDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Shuai FuDepartment of Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250012, China.
Yaohai WuDepartment of Organ Transplantation, Qilu Hospital of Shandong University, Jinan, 250012, China.
Yingzhao ShaoDepartment of Neurosurgery, Qilu Hospital of Shandong University, Institute of Brain and Brain-Inspired Science, Shandong University, Shandong Key Laboratory of Brain Health and Function Remodeling, Jinan, 250012, China.
Dongchen LiDepartment of Neurosurgery, Qilu Hospital of Shandong University, Institute of Brain and Brain-Inspired Science, Shandong University, Shandong Key Laboratory of Brain Health and Function Remodeling, Jinan, 250012, China.
Yingwen WangDepartment of Neurosurgery, Qilu Hospital of Shandong University, Institute of Brain and Brain-Inspired Science, Shandong University, Shandong Key Laboratory of Brain Health and Function Remodeling, Jinan, 250012, China.
Lingchang ZhangDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Aijing ZhangDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Yuxiang MengDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Zhongwei ZhaoDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Jiaqi LiAce Pet products Co., Ltd, Qingdao, 266000, China.
Zhao ZhangDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.
Huimin GengDepartment of Neurosurgery, Qilu Hospital of Shandong University, Institute of Brain and Brain-Inspired Science, Shandong University, Shandong Key Laboratory of Brain Health and Function Remodeling, Jinan, 250012, China.
Nengwang YuDepartment of Urology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, and the School of Biomedical Engineering, Shandong University, Jinan, Shandong, 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor's antioxidant defenses restrict the efficacy of standard therapies, resulting in compromised treatment responses and systemic tolerance. Conventional redox-disrupting strategies, designed to generate reactive oxygen species (ROS), are limited by both their reliance on single generation methods and the rapid clearance. Herein, we report an innovative strategy that employs spermine oxidase (SMOX) to catalyze the production of endogenous and highly cytotoxic acrolein, thereby creating a destructive carbonyl stress microenvironment to potentiate antineoplastic drug's efficacy. As an example, SMOX and doxorubicin (DOX) were conjugated and co-encapsulated within mesoporous silica nanoparticles to form an integrated delivery platform (PMD). Notably,

Indexed as

AcroleinBladder cancerCarbonyl stressChemotherapyPolyamine

Identifiers

PMID42182871
PMCPMC13196102

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.