Engineered acetylcholinesterase-loaded dissolvable microneedles mitigate dermal toxicity by targeting trichlorfon binding and metabolic pathway modulation.

Shuoqi Jiang, Zi-Wei Zheng, Qiuya Gu, Jian-Xin Li, Xiaobin Yu, Zhuangwei Zhang

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuoqi JiangDigital Industry Research Institute, Zhejiang Wanli University, No.8 South Qian Hu Road, Ningbo, Zhejiang, China.

Zi-Wei ZhengDigital Industry Research Institute, Zhejiang Wanli University, No.8 South Qian Hu Road, Ningbo, Zhejiang, China.

Qiuya GuKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Li-Hu Road, Bin-Hu District, Wuxi, Jiangsu, China.

Jian-Xin LiState Key Laboratory of Analytical Chemistry for Life Science, Collaborative Innovation Centre of Chemistry for Life Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, China.

Xiaobin YuKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Li-Hu Road, Bin-Hu District, Wuxi, Jiangsu, China.

Zhuangwei ZhangCentral Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trichlorfon (TCF), a widely used organophosphorus pesticide for crop protection, poses severe dermal toxicity risks as it readily penetrates the epidermal barrier and metabolizes into the more toxic dichlorvos (DDVP), triggering neurotoxicity, oxidative stress and inflammatory damage in exposed individuals. As a promising stoichiometric bioscavenger for pesticide detoxification, natural acetylcholinesterase (AChE) is still plagued by bottlenecks in thermal stability and transdermal delivery efficiency. To address these issues, this study employed a previously engineered high-activity and thermostable AChE variant (

Indexed as

AcetylcholinesteraseExogenous enzyme therapyMicroneedlesTargeted detoxificationTrichlorfon

Identifiers

PMID42182869

DOI10.1016/j.mtbio.2026.103243

PMCPMC13197772

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.